Understanding of Quorum – Sensing: A Possible Solution for Drug Resistance in Bacteria

Quorum – sensing (QS) is a cell-to-cell communication in bacteria, which leads to gene expression within a bacterial community. Using QS, bacteria regulate those genes involved in invasion and spread of the pathogens. It can occur in a group of a same bacterial species as well as, between different species. The possible role of understanding of QS and its inhibition in the treatment of infective disorders is promising. The present day therapy against infectious disease is mostly dependent on antibiotic treatment. Antibiotic therapy elicits strong selective pressure on bacteria and thereby, development of drug resistance mechanism in them. Blocking cell-to-cell communication by QS may act as an important tool to disturb their group action. QS depend on secretion of small signaling molecules by bacteria. Sometimes it directly International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 2(2016) pp. 540-546 Journal homepage: http://www.ijcmas.com